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Highly potent, non-basic 5-HT6 ligands. Site mutagenesis evidence for a second binding mode at 5-HT6 for antagonism

R. N. III HARRIS, Russel S. Stabler, David B. Repke, James M. Kress, Keith A. M. Walker, Renée S. Martin, Julie M. Brothers, Mariola Ilnicka, Simon W. Lee, Tara Mirzadegan

Bioorganic & Medicinal Chemistry Letters · 2010 · 40 citations · 34 references

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References

34

Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

Frederick J. Monsma, Yong Shen, Raymond P. Ward et al. · Molecular Pharmacology · 1993 · 598 citations · Full text

, , +17

New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies

Ramy Farid, Tyler Day, Richard A. Friesner et al. · Bioorganic & Medicinal Chemistry · 2006 · 504 citations

, , +17

A General Palladium-Catalyzed Coupling of Aryl Bromides/Triflates and Thiols

Takahiro Itoh, Toshiaki Mase · Organic Letters · 2004 · 472 citations

, , +10

A Novel Rat Serotonin (5-HT6) Receptor: Molecular Cloning, Localization and Stimulation of cAMP Accumulation

Martial Ruat, Élisabeth Traiffort, J.M. Arrang et al. · Biochemical and Biophysical Research Communications · 1993 · 411 citations

, , +16

The 5-HT6 Receptor Antagonist SB-271046 Selectively Enhances Excitatory Neurotransmission in the Rat Frontal Cortex and Hippocampus

Lee A. Dawson · Neuropsychopharmacology · 2001 · 237 citations · Full text

, , +12