Concepedia

iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes

Yun Cai, Shi Qiu, Xing Gao, Shou-Zhi Gu, Zejun Liu

APOPTOSIS · 2012 · 44 citations · 19 references

DOI

Concepts

References

19

p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities

Annie Yang, Mourad Kaghad, Yunmei Wang et al. · Molecular Cell · 1998 · 2.1K citations · Full text

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p73 is a human p53-related protein that can induce apoptosis

Christine A. Jost, María C. Marín, William G. Kaelin · Nature · 1997 · 953 citations

, , +11

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

Elsa R. Flores, Kenneth Y. Tsai, Denise Crowley et al. · Nature · 2002 · 804 citations

, , +14

ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

Yardena Samuels-Lev, Daniel O’Connor, Daniele Bergamaschi et al. · Molecular Cell · 2001 · 664 citations · Full text

, , +14

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human

Daniele Bergamaschi, Yardena Samuels, Nigel J. O’Neil et al. · Nature Genetics · 2003 · 374 citations

, , +11