William G. Kaelin

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

Michael Ohh, Cheol Won Park, Mircea Ivan et al. · Nature Cell Biology · 2000 · 1.6K citations

Life Sciences, Cell Biology, Molecular Biology +12

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

Gang Lu, Richard E. Middleton, Huahang Sun et al. · Science · 2013 · 1.6K citations · Full text

Medicine, Molecular Biology, Oncology +14

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

James Brugarolas, Kui Lei, Rebecca L. Hurley et al. · Genes & Development · 2004 · 1.4K citations · Full text

Medicine, Cell Biology, Oncology +17

Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

Diana Miao, Claire A. Margolis, Wenhua Gao et al. · Science · 2018 · 1.3K citations · Full text

Medicine, Molecular Genetics, Oncology +17