MODULATION OF PLATELET AGGREGATION IN BABOONS: IMPLICATIONS FOR MIXED CHIMERISM IN XENOTRANSPLANTATION. I. THE ROLES OF INDIVIDUAL COMPONENTS OF A TRANSPLANTATION CONDITIONING REGIMEN AND OF PIG PERIPHERAL BLOOD PROGENITOR CELLS

Abstract

Aggregation of baboon platelets and TM is directly induced by PBPCs, but not by individual components of the conditioning regimen. GPIIb/IIIa antagonists, such as eptifibatide, interfere directly with xenogeneic PBPC-platelet interactions and may further ameliorate TM in the pig-to-primate model.