New Journal of Chemistry · 2005 · 56 citations · 12 references
PharmacyChemical EngineeringChemistryCatalysisCombinatorial ChemistryReaction EngineeringCatalytic MechanismsCatalytic Reaction EngineeringCombinatorial SynthesisDisulfide Bond FormationDiversity-oriented SynthesisDynamic Combinatorial ChemistryCatalytic Reaction MechanismsChemoselective Library SynthesisCombinatorial Library DesignCombinatorial Library ScreeningCombinatorial Library SynthesisDynamic Combinatorial CatalysisDynamic Combinatorial Macrocycle SynthesisHydrolysis
A transition-state analogue (TSA) for an acetal hydrolysis reaction was found to select and amplify a macrocycle from a dynamic combinatorial library (DCL) of disulfides in water. This host was able to accelerate the reaction by a factor of two; a similar value was progressively reached when the macrocycle was gradually produced in the course of the reaction.
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