Phosphorus, sulfur, and silicon and the related elements · 2009 · 17 citations · 26 references
Natural SciencesChemistryMolecular BiologyBiophysical ChemistryNucleic Acid ChemistrySpectroscopyBase PairingDna ChemistryDna StabilityDna StructureMicrowave-assisted SynthesisOligonucleotide ChemistryAbsorption SpectraBinding ConstantsDna Base PairingDna CleavageDna Cleavage MechanismPhotocleavage Of Nucleic AcidsThermal Denaturation StudiesThermal Dna Denaturation
We have characterized a new class of 2-thieno/2-selenopyrano[2,3-b]quinolin-2-ol (2c/3c) intercalators exhibiting a novel type of DNA binding and photocleavage activity. The dynamic behavior of these compounds with DNA was investigated by absorption spectra (obtained Kb constant for 2c is 3.6 × 106 and for 3c is 2.8 × 105), viscosity, and thermal denaturation studies. Intrinsic binding constants (Kb) have been estimated under a similar set of experimental conditions. An absorption spectral study shows the strong interaction between synthesized 2c, 3c, and base pairs CT-DNA. In addition, the effects of these compounds on DNA cleavage were investigated by photoirradiation at 360 nm and show that the hybrids effectively cleaved double-stranded DNA with UV light of a long wavelength and without any additive.
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William J. Blot, Jingyuan Li, Phil R. Taylor et al. · JNCI Journal of the National Cancer Institute · 1993 · 1.8K citations
On demonstrating DNA intercalation
Eric C. Long, Jacqueline K. Barton · Accounts of Chemical Research · 1990 · 880 citations