Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

Anne Kingston, Paul L. Ornstein, Rebecca A. Wright et al. · Neuropharmacology · 1998 · 364 citations

Functional Selectivity, Medicine, Drug Discovery +7

(+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors

Barry P. Clark, Stephen Baker, John Goldsworthy et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 134 citations

G Protein-coupled Receptor, Medicine, Functional Selectivity +3

Pharmacological analysis of 4-carboxyphenylglycine derivatives: Comparison of effects on mGluR1α and mGluR5a subtypes

Ann E. Kingston, J. Paul Burnett, Nancy G. Mayne et al. · Neuropharmacology · 1995 · 89 citations

Molecular Pharmacology, Pharmacological Study, Biochemistry +9

Direct effects of metabotropic glutamate receptor compounds on native and recombinant <i>N</i> -methyl- <scp>d</scp> -aspartate receptors

Anis Contractor, Robert W. Gereau, Tim Green et al. · Proceedings of the National Academy of Sciences · 1998 · 74 citations · Full text

Neurotransmitter, Pharmacotherapy, Experimental Pharmacology +18

Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists

Joseph P. Tizzano, Kelly I. Griffey, J. A. Johnson et al. · Neuroscience Letters · 1993 · 51 citations

Intracerebral 1S,3r-1-aminocyclopentane-1,3-dicarboxylic Acid, Neurophysiology, Neuroanatomy +11