Concepedia

Mite Allergen Der-p2 Triggers Human B Lymphocyte Activation and Toll-Like Receptor-4 Induction

Jaw Ji Tsai, Shing‐Hwa Liu, Sui Yin, Cheng Yang, Hong Sheng Hsu, Wen Bao Chen, En Chih Liao, Wen Jane Lee, Hung Chuan Pan, Meei‐Ling Sheu

PLoS ONE · 2011 · 36 citations · 22 references

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Abstract

These results strongly suggest that Der-p2 is capable of triggering B cell activation and MKP-1-activated p38/MAPK dephosphorylation-regulated TLR4 induction, which subsequently enhances host immune, defense responses and development of effective allergic disease therapeutics in B cells.

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