Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia

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Heng Li, Richard Durbin · Bioinformatics · 2009 · 62.8K citations · Full text

Life Sciences, Bioinformatics, Biology +12

VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

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Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads

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Life Sciences, Bioinformatics, Genetics +17

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Estela Jacinto, Robbie Loewith, Anja Schmidt et al. · Nature Cell Biology · 2004 · 2.1K citations

Life Sciences, Cell Biology, Molecular Biology +14

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

Jeffrey A. Engelman, Liang Chen, Xiaohong Tan et al. · Nature Medicine · 2008 · 1.3K citations · Full text

Medicine, Oncology, Pharmacology +17