The <i>PTPN22</i> R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case–control samples

Abstract

Our findings indicate that the minor allele of the PTPN22 R263Q polymorphism is associated with a lower risk of RA. This association is independent of the well-established association between PTPN22 R620W and RA. Both polymorphisms have an additive effect on the risk of RA.