A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis

Ann B. Begovich, Victoria Carlton, Lee Honigberg, +25

The American Journal of Human Genetics

Rheumatoid DisorderRheumatologyProtein Tyrosine PhosphataseAutoimmune DiseaseDisease Mechanism +11

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

Rajan P. Nair, Kristina Callis Duffin, Cynthia Helms, +27

Nature Genetics

InflammationCytokineImmune Cell DevelopmentMedicineImmune Regulation +5

A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes

Michele Cargill, Steven J. Schrodi, Monica Chang, +17

The American Journal of Human Genetics

InflammationImmunogeneticsMedicineImmunologyGenetic Epidemiology +7

Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE

Chieko Kyogoku, Ward Ortmann, Annette Lee, +19

The American Journal of Human Genetics

Signal TransductionGenetic DisorderGeneticsGenetic EpidemiologyHuman Polymorphism +9

Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes

Lindsey A. Criswell, Kirsten A. Pfeiffer, Raymond F. Lum, +11

The American Journal of Human Genetics

Genome-wide Association StudyAllelic VariantAutoimmune DiseaseGeneticsImmunology +10

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

Jorge R. Oksenberg, Michael Panzara, Ann B. Begovich, +7

Nature

Brain LesionsNeurological DisorderMedicineImmunologyBrain-immune Interaction +6

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

Jorge R. Oksenberg, Simon J. Stuart, Ann B. Begovich, +3

Nature

Multiple Sclerosis PatientsNeurological DisorderMedicineImmunologyLimited Heterogeneity +6

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

Soumya Raychaudhuri, Brian Thomson, Elaine F. Remmers, +59

Nature Genetics

Rheumatoid DisorderRheumatologyGenetic VariantsAutoimmune DiseaseRheumatic Diseases +10

REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

Peter K. Gregersen, C. I. Amos, Annette T. Lee, +14

Nature Genetics

ImmunologyPathologyInflammatory ArthritisInflammationRheumatoid Disorder +15

Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis

Lisa F. Barcellos, Stephen Sawcer, Patricia P. Ramsay, +16

Human Molecular Genetics

Neurological DisorderGeneticsImmunologyGenetic EpidemiologyPathology +14