Concepedia

Identification of Tyrosine-9 of MAVS as Critical Target for Inducible Phosphorylation That Determines Activation

Chaoyang Wen, Zhifeng Yan, Xiaoli Yang, Kai Guan, Changzhi Xu, Ting Song, Zirui Zheng, Wenjun Wang, Ying Wang, Man Zhao,

PLoS ONE · 2012 · 19 citations · 22 references

DOIFull text

Open access

Abstract

These experiments identify a novel residue of MAVS that is crucially involved in the recruitment of TRAF3/TRAF6 and in downstream propagation of MAVS signaling.

References

22

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

Rashu B. Seth, Lijun Sun, Chee-Kwee Ea et al. · Cell · 2005 · 3.2K citations · Full text

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Taro Kawai, Ken Takahashi, Shintaro Sato et al. · Nature Immunology · 2005 · 2.5K citations

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

Etienne Meylan, Joseph Curran, Kay Hofmann et al. · Nature · 2005 · 2.4K citations · Full text

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VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

Liang‐Guo Xu, Yan‐Yi Wang, Ke-Jun Han et al. · Molecular Cell · 2005 · 1.8K citations · Full text

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MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

Fajian Hou, Lijun Sun, Hui Zheng et al. · Cell · 2011 · 1.2K citations · Full text

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