General synthetic access to α-allenyl amines and α-allenyl-α-aminoacids as potential enzyme activated irreversible inhibitors of PLP dependent enzymes

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

Brian W. Metcalf, Philippe Bey, Charles Danzin et al. · Journal of the American Chemical Society · 1978 · 1K citations

Life Sciences, Pharmacology, Biocatalysis +16

Selective inhibitors of biosynthesis of aminergic neurotransmitters

J. Kollonitsch, Arthur A. Patchett, Stephen Marburg et al. · Nature · 1978 · 426 citations

Life Sciences, Neuroscience, Pharmacology +14

4‐Amino‐hex‐5‐enoic Acid, a Selective Catalytic Inhibitor of 4‐Aminobutyric‐Acid Aminotransferase in Mammalian Brain

Bruce Lippert, Brian W. Metcalf, Michel J. Jung et al. · European Journal of Biochemistry · 1977 · 379 citations · Full text

Life Sciences, Biochemistry, Biocatalysis +15

Efficient homologation of acetylenes to allenes

Piere Crabbé, Houda Fillion, Daniel André et al. · Journal of the Chemical Society Chemical Communications · 1979 · 170 citations

Natural Sciences, Chemistry, Organic Chemistry +4

Acetylenic enzyme inactivators. Inactivation of .gamma.-cystathionase, in vitro and in vivo by propargylglycine

Robert H. Abeles, Christopher T. Walsh · Journal of the American Chemical Society · 1973 · 143 citations

Life Sciences, Biochemistry, Pharmacology +12