FEBS Letters · 2005 · 18 citations · 24 references
MedicineHematologyMolecular BiologyCell SignalingHemostasisSignal TransductionPlatelet ActivationPlatelet AggregationPlatelet FunctionPlatelet PhysiologyThrombin GenerationThrombosisHepatocyte Growth Factor Receptor SignalingHepatocyte Growth Factor SignalingPlatelet Receptor-ligand InteractionsPlatelet Surface ReceptorsPlatelet-dependent Thrombin GenerationPlatelet-derived Growth Factor ReceptorsThrombin-induced Platelet AggregationThrombin-mediated Platelet Activation
Circulating HGF is significantly increased in a number of thrombus-associated disorders. Since platelets play a pivotal role in thrombogenesis, the ability of HGF to interact with human platelets was investigated. This paper shows for the first time that human platelets express HGF receptor, the tyrosine kinase encoded by c-MET gene. At physiological concentrations HGF was found to inhibit both glycoprotein (alpha)IIb(beta)3 activation and thrombin-dependent platelet aggregation in a dose- and time-dependent manner. These results suggest that circulating HGF may counteract thrombogenesis by negatively modulating platelet functions.
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