Mechanisms of clinical resistance by HIV-I variants to zidovudine and the paradox of reverse transcriptase sensitivity

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

Lori A. Kohlstaedt, J Wang, Jonathan M. Friedman et al. · Science · 1992 · 1.9K citations

Life Sciences, Biochemistry, Molecular Biology +17

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

B. A. Larder, G. Darby, Douglas D. Richman · Science · 1989 · 1.6K citations

Medicine, Infectious Diseases, Pharmacology +17

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

Jerome A. Zack, Salvatore J. Arrigo, Stacy Weitsman et al. · Cell · 1990 · 1.5K citations

Life Sciences, Cell Biology, Molecular Biology +17

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

P A Furman, James A. Fyfe, M H St Clair et al. · Proceedings of the National Academy of Sciences · 1986 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +8

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

Brendan Larder, Sharon D. Kemp · Science · 1989 · 1.2K citations

Life Sciences, Microbiology, Molecular Genetics +17