Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Jay D. Horton, Joseph L. Goldstein, Michael S. Brown · Journal of Clinical Investigation · 2002 · 3.9K citations · Full text

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Konrad T. Howitz, Kevin J. Bitterman, Haim Cohen et al. · Nature · 2003 · 3.7K citations

Lifespan Extension, Natural Sciences, Molecular Biology +5

The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases

Rebecca L. Hurley, Kristin A. Anderson, Jeanne M. Franzone et al. · Journal of Biological Chemistry · 2005 · 1K citations · Full text

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

Xiuyun Hou, Shanqin Xu, Karlene A. Maitland-Toolan et al. · Journal of Biological Chemistry · 2008 · 774 citations · Full text

Polyphenol-activated Sirt1, Sirt1 Functions, Oxidative Stress +17

The nuclear receptor LXR is a glucose sensor

Nico Mitro, Puiying A. Mak, Leo Vargas et al. · Nature · 2006 · 512 citations

Nuclear Receptor Lxr, Signal Transduction, G Protein-coupled Receptor +3