Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Hidenori Ichijo, Eisuke Nishida, Kenji Irie et al. · Science · 1997 · 2.3K citations

Life Sciences, Cell Biology, Molecular Biology +16

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

Christophe Fleury, Maria Neverova, Sheila Collins et al. · Nature Genetics · 1997 · 1.6K citations

Medicine, Endocrinology, Genetics +12

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Hideki Nishitoh, Atsushi Matsuzawa, Kei Tobiume et al. · Genes & Development · 2002 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

Kei Tobiume, Atsushi Matsuzawa, Takumi Takahashi et al. · EMBO Reports · 2001 · 1.2K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

Denis Arsenijevic, Hiroki Onuma, Claire Pecqueur et al. · Nature Genetics · 2000 · 1.1K citations

Life Sciences, Genetics, Immunology +16