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Design driven HtL: The discovery and synthesis of new high efficacy β2-agonists

Michael J. Stocks, Lilian Alcaraz, Andrew Bailey, Roger V. Bonnert, Elaine Cadogan, Jadeen Christie, Stephen Connolly, Anthony R. Cook, Adrian J. Fisher, Alice W. Flaherty,

Bioorganic & Medicinal Chemistry Letters · 2011 · 23 citations · 19 references

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19

High-Resolution Crystal Structure of an Engineered Human β <sub>2</sub> -Adrenergic G Protein–Coupled Receptor

Vadim Cherezov, Daniel M. Rosenbaum, Michael A. Hanson et al. · Science · 2007 · 3.3K citations · Full text

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Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.

Catherine D. Strader, Irving S. Sigal, Mari R. Candelore et al. · Journal of Biological Chemistry · 1988 · 540 citations · Full text

, , +7

Identification of Two Serine Residues Involved in Agonist Activation of the β-Adrenergic Receptor

Catherine D. Strader, Mari R. Candelore, W S Hill et al. · Journal of Biological Chemistry · 1989 · 530 citations · Full text

, , +13

Location of Trp265 in Metarhodopsin II: Implications for the Activation Mechanism of the Visual Receptor Rhodopsin

Evan Crocker, Markus Eilers, Shivani Ahuja et al. · Journal of Molecular Biology · 2006 · 133 citations

, , +12

The Identification of Indacaterol as an Ultralong-Acting Inhaled β<sub>2</sub>-Adrenoceptor Agonist

François Baur, David T. Beattie, David Beer et al. · Journal of Medicinal Chemistry · 2010 · 104 citations · Full text

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