The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin.

Abstract

Five new dibenzocyclooctadiene lignans, named gomisin A (2), B (3), C (4), F (5) and G (6), were isolated from the petroleum ether extract of fruits of Schizandra chinensis BAILL. (Schizandraceae) and their absolute structures were elucidated by chemical and spectral techniques. The absolute structure of schizandrin (1), the plane structure of which had already been elucidated by Kochetkov et al., was also elucidated on the basis of spectroscopic results.