Biologically active heparin-like fragments with a “non-glycosamino”glycan structure. Part 3 : o-alkylated-o-sulphated pentasaccharides.

Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

J Choay, Maurice Petitou, J C Lormeau et al. · Biochemical and Biophysical Research Communications · 1983 · 652 citations

Life Sciences, Biochemistry, Molecular Biology +14

Synthesis of heparin fragments: A methyl α-pentaoside with high affinity for antithrombin III

Maurice Petitou, Philippe Duchaussoy, Isidore Lederman et al. · Carbohydrate Research · 1987 · 155 citations

Medicine, Biochemistry, Medicinal Chemistry +12

Constructing a molecular model of the interaction between antithrombin III and a potent heparin analog

Peter D. J. Grootenhuis, C. A. A. VAN BOECKEL · Journal of the American Chemical Society · 1991 · 113 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Conformation of the pentasaccharide corresponding to the binding site of heparin for antithrombin III

Massimo Ragazzi, Dino R. Ferro, Bruno Perly et al. · Carbohydrate Research · 1990 · 92 citations

Life Sciences, Biochemistry, Molecular Biology +12

Synthesis of a potent antithrombin activating pentasaccharide: A new heparin-like fragment containing two 3-O-sulphated glucosamines

C. A. A. VAN BOECKEL, T. Beetz, S. F. VAN AELST · Tetrahedron Letters · 1988 · 52 citations

Life Sciences, Biochemistry, Pharmacology +13