Synthesis of thrombin-inhibiting heparin mimetics without side effects

Maurice Petitou, Jean-Pascal Hérault, A. Bernat, +4

Nature

ThrombopoiesisThrombosisThrombin-inhibiting Heparin MimeticsBlood PlateletMedicine +5

Total synthesis of a heparin pentasaccharide fragment having high affinity for antithrombin III

Pierre Sînaÿ, Jean‐Claude Jacquinet, Maurice Petitou, +4

Carbohydrate Research

Medicinal ChemistryBiochemistryNatural SciencesAntithrombin IiiTotal Synthesis +4

Synthesis of heparin fragments: A methyl α-pentaoside with high affinity for antithrombin III

Maurice Petitou, Philippe Duchaussoy, Isidore Lederman, +4

Carbohydrate Research

BiochemistryNatural SciencesAntithrombin IiiPeptide ScienceHeparin Fragments +3

Synthesis of heparin fragments. A chemical synthesis of the pentasaccharide O-(2-deoxy-2-sulfamido-6-O-sulfo-α-d-glucopyranosyl)-(1→4)-O-(β-d-glucopyranosyluronic acid)-(1→4)-O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-α-d-glucopyranosyl)-(1→4)-O-(2-O-sulfo-α-l-idopyranosyluronic acid)-(1→4)-2-deoxy-2-sulfamido-6-O-sulfo-d-glucopyranose decasodium salt, a heparin fragment having high affinity for antithrombin III

Maurice Petitou, Philippe Duchaussoy, Isidore Lederman, +4

Carbohydrate Research

Bioorganic ChemistryBiochemistryNatural SciencesMedicineGlycobiology +8

Synthesis of heparin fragments. A chemical synthesis of the trisaccharide O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-α-d-glucopyranosyl)-(1→4)-O-(2-O-sulfo-α-l-idopyranosyluronic acid)-(1→4)-2-deoxy-2-sulfamido-6-O-sulfo-d-glucopyranose heptasodium salt

Jean‐Claude Jacquinet, Maurice Petitou, Philippe Duchaussoy, +4

Carbohydrate Research

BiosynthesisBioorganic ChemistryEngineeringBiochemistryNatural Sciences +8

ChemInform Abstract: Synthesis of Heparin Fragments. A Chemical Synthesis of the Pentasaccharide O‐(2‐Deoxy‐2‐sulfamido‐6‐O‐sulfo‐α‐D‐glucopyranosyl)‐(l‐>4)‐O‐(β‐glucopyranosyluronic acid)‐(1‐>4)‐O‐(2‐deoxy‐2‐sulfamido‐3,6‐di‐O‐ sulfo‐α‐D‐glucopyranosyl)‐(1‐>4)‐O‐(2‐O‐sulfo‐α‐L‐idopyranosyluronic acid)‐(l‐>4)‐2‐deoxy‐2‐sulfamido‐6‐O‐sulfo‐D‐glucopyranose Decasodium Salt (I), a Heparin Fragment having High Affinity for Antithrombin III.

Maurice Petitou, Philippe Duchaussoy, Isidore Lederman, +4

Chemischer Informationsdienst

BiochemistryMedicineGlycobiologyAntithrombin IiiHeparin Fragments +5

Synthesis of Conformationally Lockedl-Iduronic Acid Derivatives: Direct Evidence for a Critical Role of the Skew-Boat2S0 Conformer in the Activation of Antithrombin by Heparin

Sanjoy K. Das, Jean‐Maurice Mallet, Jacques Esnault, +7

Chemistry - A European Journal

Combinatorial ChemistryMolecular RecognitionConformationally Lockedl-iduronic AcidSkew-boat2s0 ConformerBiochemistry +12

Binding of heparin to antithrombin III: A chemical proof of the critical role played by a 3-sulfated 2-amino-2-deoxy-d-glucose residue

Maurice Petitou, Philippe Duchaussoy, Isidore Lederman, +2

Carbohydrate Research

BiochemistryProtein FoldingCritical RoleBioanalysisGlycobiology +8

Reversible biotinylated oligosaccharides: a new approach for a better management of anticoagulant therapy

Pierre Savi, J P Hérault, Philippe Duchaussoy, +5

Journal of Thrombosis and Haemostasis

ThrombosisGlycobiologyPharmacologyNew ApproachPolysaccharide +7

First Synthetic Carbohydrates with the Full Anticoagulant Properties of Heparin

Maurice Petitou, Philippe Duchaussoy, Pierre‐A. Driguez, +5

Angewandte Chemie International Edition

Inhibit ThrombinGlycobiologyPolysaccharideThrombosisFirst Synthetic Carbohydrates +16