From Models to Molecules:  Opioid Receptor Dimers, Bivalent Ligands, and Selective Opioid Receptor Probes

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

W R Martin, C. G. Eades, JP Thompson et al. · Journal of Pharmacology and Experimental Therapeutics · 1976 · 3K citations

Medicine, Pharmacology, Veterinary Pharmacology +16

Endogenous opioid peptides: multiple agonists and receptors

John A.H. Lord, Angela A. Waterfield, John Hughes et al. · Nature · 1977 · 2.5K citations

Medicine, Pharmacology, Neuroendocrinology +9

A potent and selective endogenous agonist for the µ-opiate receptor

James E. Zadina, Laszlo Hackler, Lin-Jun Ge et al. · Nature · 1997 · 1.3K citations

Medicine, Medicinal Chemistry, Pharmacology +12

Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

David Farrens, Christian Altenbach, Ke Yang et al. · Science · 1996 · 1.2K citations

Life Sciences, Biochemistry, Biophysics +17

G-protein-coupled receptor heterodimerization modulates receptor function

Bryen A. Jordan, Lakshmi A. Devi · Nature · 1999 · 1.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12