G-protein-coupled receptor heterodimerization modulates receptor function

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Endogenous opioid peptides: multiple agonists and receptors

John A.H. Lord, Angela A. Waterfield, John Hughes et al. · Nature · 1977 · 2.5K citations

Medicine, Pharmacology, Neuroendocrinology +9

GABAB-receptor subtypes assemble into functional heteromeric complexes

Klemens Kaupmann, Barbara Malitschek, Valérie Schuler et al. · Nature · 1998 · 1.2K citations

Medicine, Neurobiology, Pharmacology +14

Heterodimerization is required for the formation of a functional GABAB receptor

Julia H. White, Alan Wise, Martin J. Main et al. · Nature · 1998 · 1.2K citations

Life Sciences, Molecular Biology, Neuroscience +11

GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2

Kenneth A. Jones, Beth Borowsky, Joe A. Tamm et al. · Nature · 1998 · 1.1K citations

Medicine, Neuroscience, Pharmacology +14