Concepedia

Bivalent Binding

Bivalent Binding is a molecular interaction mechanism in immunology whereby an immunoglobulin molecule binds simultaneously to two identical antigenic epitopes through its dual antigen-binding sites, thereby enhancing avidity and functional specificity in immune responses.

753

Publications

40.7K

Citations

3.6K

Authors

938

Institutions

Publications per year

2017–2026

147

Parents

Publications

753

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

Haihong Zhong, Reinhard Voll, Sankar Ghosh · Molecular Cell · 1998 · 1.2K citations · Full text

, , +11

"Diabodies": small bivalent and bispecific antibody fragments.

Philipp Holliger, Teresa Di Prospero, Greg Winter · Proceedings of the National Academy of Sciences · 1993 · 875 citations · Full text

, , +17

Chitin-Induced Dimerization Activates a Plant Immune Receptor

Tingting Liu, Zixu Liu, Chuanjun Song et al. · Science · 2012 · 673 citations

, , +17

The kinetics of antibody binding to membrane antigens in solution and at the cell surface

David W. Mason, Alan F. Williams · Biochemical Journal · 1980 · 568 citations · Full text

, , +15

PSD-95 Assembles a Ternary Complex with theN-Methyl-d-aspartic Acid Receptor and a Bivalent Neuronal NO Synthase PDZ Domain

Karen S. Christopherson, Brian J. Hillier, Wendell A. Lim et al. · Journal of Biological Chemistry · 1999 · 540 citations · Full text

, , +14

1–5 of 753

Authors

3.6K

  1. PS
    Philip S. Portoghese

    University of Minnesota, United States

    15 publications · 1.1K citations

    15

    h-index

  2. DH
    David Holowka

    Cornell University, United States

    8 publications · 275 citations

    8

    h-index

  3. BG
    Byron Goldstein

    Los Alamos National Laboratory, United States

    8 publications · 190 citations

    8

    h-index

  4. BB
    Barbara Baird

    Cornell University, United States

    8 publications · 275 citations

    8

    h-index

  5. EA
    Eyup Akgün

    University of Minnesota, United States

    7 publications · 339 citations

    7

    h-index

1–5 of 3.6K

Institutions

938

  1. National Institutes of Health

    Bethesda, United States

    20 h-index

    72 publications

    5.3K citations

  2. University of Minnesota

    Minneapolis, United States

    17 h-index

    73 publications

    4.7K citations

  3. Harvard University

    Cambridge, United States

    17 h-index

    64 publications

    5K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    90 publications

    4.4K citations

  5. Inserm

    Paris, France

    13 h-index

    47 publications

    2.2K citations

  6. Cornell University

    Ithaca, United States

    13 h-index

    46 publications

    1.6K citations

  7. Los Alamos National Laboratory

    Los Alamos, United States

    11 h-index

    28 publications

    647 citations

  8. University of Washington

    Seattle, United States

    11 h-index

    48 publications

    2.5K citations

1–8 of 938

Venues

  1. Journal of Medicinal Chemistry

    42 publications · 2.1K citations

    29

    h-index

  2. Journal of Biological Chemistry

    JBC · 29 publications · 2.1K citations

    22

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 23 publications · 3.4K citations

    22

    h-index

  4. Journal of the American Chemical Society

    JACS · 23 publications · 2.6K citations

    21

    h-index

  5. The Journal of Immunology

    JI · 30 publications · 1.9K citations

    21

    h-index

1–5