Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception

Eyup Akgün, Muhammad I. Javed, Mary M. Lunzer, +3

Proceedings of the National Academy of Sciences

Bivalent Ligands That Target μ Opioid (MOP) and Cannabinoid1 (CB₁) Receptors Are Potent Analgesics Devoid of Tolerance

Morgan Le Naour, Eyup Akgün, Ajay Yekkirala, +4

Journal of Medicinal Chemistry

Target μ OpioidPain DisordersPain MedicineMolecular PainPharmacotherapy +19

Mixed-ligand Copper(II) Complexes: Investigation of their Spectroscopic, Catalysis, Antimicrobial and Potentiometric Properties

Mehmet Tümer, Nihal Deligönül, Ayşegül Gölcü, +4

Transition Metal Chemistry

Inorganic ChemistryChemical EngineeringEngineeringMixed-ligand CopperCoordination Complex +5

Combined Glia Inhibition and Opioid Receptor Agonism Afford Highly Potent Analgesics without Tolerance

Eyup Akgün, Mary M. Lunzer, Philip S. Portoghese

ACS Chemical Neuroscience

Chronic Inflammatory PainPain MedicineMolecular PainPharmacotherapyChronic Use +21

Induced Association of μ Opioid (MOP) and Type 2 Cholecystokinin (CCK₂) Receptors by Novel Bivalent Ligands

Yaguo Zheng, Eyup Akgün, Kaleeckal G. Harikumar, +5

Journal of Medicinal Chemistry

Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR₅)

Eyup Akgün, Muhammad I. Javed, Mary M. Lunzer, +4

Journal of Medicinal Chemistry

Synthesis and characterization of Schiff base metal complexes: their antimicrobial, genotoxicity and electrochemical properties

Mehmet Tümer, Eyup Akgün, Sevil Toroğlu, +2

Journal of Coordination Chemistry

Inorganic ChemistryChemical EngineeringRuiii Metal ComplexesEngineeringCoordination Complex +8

Asymmetric synthesis of β-lactams and n-benzoyl-3-phenylisoserines via the staudinger reaction

Gunda I. Georg, Peter M. Mashava, Eyup Akgün, +1

Tetrahedron Letters

Enantioselective SynthesisNatural SciencesDiversity-oriented SynthesisOrganic ChemistryStereoselective Synthesis +4

Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model

Branden A. Smeester, Mary M. Lunzer, Eyup Akgün, +2

European Journal of Pharmacology

Pain MedicineMedicineCancer PainMolecular PainNeuropharmacology +7

Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice

Cristina D. Peterson, Kelley F. Kitto, Eyup Akgün, +6

Pain

Pain TherapyPain MedicineImmunologyNeuropathic PainMolecular Pain +17