Hypothalamic S1P/S1PR1 axis controls energy homeostasis

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Michael A. Cowley, James L. Smart, Marcelo Rubinstein et al. · Nature · 2001 · 2.3K citations

Neuropeptides, Anorexigenic Pomc Neurons, Arcuate Nucleus +13

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

Xiaoqing Zhang, Guo Zhang, Hai Zhang et al. · Cell · 2008 · 1.3K citations · Full text

Obesity, Metabolic Syndrome, Inflammation +8

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

Marciane Milanski, Giovanna Rosa Degasperi, Andressa Coope et al. · Journal of Neuroscience · 2009 · 1.1K citations · Full text

Immunology, Fatty Acids Produce, Inflammatory Response Predominantly +21

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

Sarah H. Bates, Walter H. Stearns, Trevor A. Dundon et al. · Nature · 2003 · 1K citations

Energy Homeostasis, Developmental Biology, Signal Transduction +11

Immortalization of hypothalamic GnRH by genetically targeted tumorigenesis

Pamela L. Mellon, Jolene J. Windle, Paul C. Goldsmith et al. · Neuron · 1990 · 953 citations

Developmental Biology, Growth Hormone, Neuroendocrine Mechanism +4