Ibudilast, a mixed PDE3/4 inhibitor, causes a selective and nitric oxide/cGMP-independent relaxation of the intracranial vertebrobasilar artery

Multiple cyclic nucleotide phosphodiesterase activities from rat brain

M. Michael Appleman, W. J. Thompson · Biochemistry · 1971 · 1.1K citations

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The Discovery of Tadalafil:  A Novel and Highly Selective PDE5 Inhibitor. 1: 5,6,11,11a-Tetrahydro-1<i>H</i>-imidazo[1‘,5‘:1,6]pyrido[3,4-<i>b</i>]indole-1,3(2<i>H</i>)-dione Analogues

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Pharmacy, Medicinal Chemistry, Pharmacology +16

Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity

Toshiki Sudo, Kazue Tachibana, Kazuyuki Toga et al. · Biochemical Pharmacology · 2000 · 176 citations

Medicine, Medicinal Chemistry, Pharmacology +14

The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family

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Characterization and selective inhibition of cyclic nucleotide phosphodiesterase isozymes in canine tracheal smooth muscle.

Theodore J. Torphy, L B Cieslinski · Molecular Pharmacology · 1990 · 128 citations

Life Sciences, Biochemistry, Pharmacology +15