Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice

A central role for JNK in obesity and insulin resistance

Jiro Hirosumi, Gürol Tuncman, Lufen Chang et al. · Nature · 2002 · 3.3K citations

Medicine, Biochemistry, Endocrinology +14

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

Vincent Aguirre, Tohru Uchida, Lynne Yenush et al. · Journal of Biological Chemistry · 2000 · 1.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1

Jiangying Zou, Yongle Guo, Toumy Guettouche et al. · Cell · 1998 · 1.2K citations

Life Sciences, Genetics, Molecular Biology +14

HSP72 protects against obesity-induced insulin resistance

Jason Chung, Anh-Khoi Nguyen, Darren C. Henstridge et al. · Proceedings of the National Academy of Sciences · 2008 · 550 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

Suzanne A. Eccles, Andy Massey, Florence I. Raynaud et al. · Cancer Research · 2008 · 478 citations · Full text

Medicine, Oncology, Pharmacology +8