A C-Ring Regioisomer of the Marine Alkaloid Meridine Exhibits Selective In Vitro Cytotoxicity for Solid Tumours

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.3K citations · Full text

Chromatin, Genome Instability, Dna Damage +12

Diels-alder reactions of azadienes

Dale L. Boger · Tetrahedron · 1983 · 626 citations

Heterocyclic, Alkene Metathesis, Diels-alder Reactions +2

Antineoplastic and antiherpetic activity of spermidine catecholamide iron chelators

Raymond J. Bergeron, Paul F. Gavanaugh, S. J. KLINE et al. · Biochemical and Biophysical Research Communications · 1984 · 139 citations

Medicinal Chemistry, Bioorganic Chemistry, Natural Sciences +6

Ascididemin, a novel pentacyclic aromatic alkaloid with potent antileukemic activity from the okinawan tunicate didemnum sp.

Jun'ichi Kobayash, Jie‐Fei Cheng, Hideshi Nakamura et al. · Tetrahedron Letters · 1988 · 139 citations

Medicinal Chemistry, Biochemistry, Medicine +9

Amphimedine, new aromatic alkaloid from a pacific sponge, Amphimedon sp. Carbon connectivity determination from natural abundance carbon-13-carbon-13 coupling constants

Francis J. Schmitz, Santosh Kumar Agarwal, Sarath P. Gunasekera et al. · Journal of the American Chemical Society · 1983 · 130 citations

Pacific Sponge, Medicinal Chemistry, Marine Biotechnology +14