The PyMOL Molecular Graphics System

Warren L. DeLano

Medical Entomology and Zoology

EngineeringMolecular BiologyMolecular GraphicMolecular RecognitionMedicine +3

NMRPipe: A multidimensional spectral processing system based on UNIX pipes

Frank Delaglio, Stephan Grzesiek, Geerten W. Vuister, +3

Journal of Biomolecular NMR

Unix PipesStream ProcessingEngineeringData ScienceMultidimensional Signal Processing +11

<i>PRODRG</i>: a tool for high-throughput crystallography of protein–ligand complexes

Alexander W. Schüttelkopf, Daan M. F. van Aalten

Acta Crystallographica Section D Biological Crystallography

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves, +9

Science

Tumor BiologySmall-molecule AntagonistsMdm2-p53 InteractionP53 FunctionChemoprevention Strategy +12

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker, +30

Nature

Tumor BiologyBcl-2 Family ProteinsMedicineSolid TumoursCell Death +7

HADDOCK:  A Protein−Protein Docking Approach Based on Biochemical or Biophysical Information

Cyril Dominguez, Rolf Boelens, Alexandre M. J. J. Bonvin

Journal of the American Chemical Society

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Mark F. van Delft, Andrew H. Wei, Kylie D. Mason, +10

Cancer Cell

ApoptosisImmunologyCell DeathAnti-cancer AgentMedicine +2

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

Marina Konopleva, Rooha Contractor, Twee Tsao, +22

Cancer Cell

Hematological MalignancyMedicineAcute Myeloid LeukemiaApoptosisHematology +9

Solution structure of the antiapoptotic protein bcl-2

Andrew M. Petros, A Medek, David G. Nettesheim, +6

Proceedings of the National Academy of Sciences

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

Kensuke Kojima, Marina Konopleva, Teresa McQueen, +3

Blood