Chemical and Pharmaceutical Bulletin · 1987 · 16 citations · 1 references
Life SciencesImmunologyPathologyImmunoregulationInflammationInnate ImmunityAntiviral ImmunityImmune ResponseInnate Immune ActivationInnate Immune ModulationInterferon ResponsesLeukocyte RecruitmentAntiviral Interferon ResponsesInterferon Gamma ProductionInterferon Gamma ResponseInterferon-gamma ResponsesInterferon-mediated Innate ImmunityType I Interferon InductionType I Interferon PathwaysType I Interferon Responses
The effects of interferons (IFNs) on Ia-like antigen expression in human peripheral blood polymorphonuclear leukocytes (PMNs) were examined in vitro using flow cytometry and FITC-labelled monoclonal antibody specific for the Ia-like antigen OKIa1. Recombinant human IFN-gamma markedly enhanced the expression of Ia-like antigen on PMNs and increased the number of Ia-positive PMNs. In contrast, natural human IFN-alpha and-beta had no effect on the expression when compared on the basis of antiviral activity.
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