The effects of 2′- and 3′-alkyl substituents on oligonucleotide hybridization and stability

Polymer support oligonucleotide synthesis XVIII^1.2): use of<i>β</i>-cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product

N. D. SINHA, J. Biernat, J. F. A. McManus et al. · Nucleic Acids Research · 1984 · 845 citations · Full text

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Marvin Charton · Journal of the American Chemical Society · 1975 · 485 citations

Altmetrics, Engineering, Chemical Analysis +9

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a powerful tool for the mass and sequence analysis of natural and modified oligonucleotides

Uwe Pieles, Werner Zürcher, Martin Schär et al. · Nucleic Acids Research · 1993 · 454 citations · Full text

Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

Andrew M. Kawasaki, Martin D. Casper, Susan M. Freier et al. · Journal of Medicinal Chemistry · 1993 · 432 citations

Bioorganic Chemistry, Molecular Biology, Duplex Stability +16

Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines

Richard W. Wagner, Mark D. Matteucci, Jason G. Lewis et al. · Science · 1993 · 406 citations

Melting Temperature, Biochemistry, Antisense Gene Inhibition +10