Multiple Global Suppressors of Protein Stability Defects Facilitate the Evolution of Extended-Spectrum TEM β-Lactamases

<i>PHENIX</i>: building new software for automated crystallographic structure determination

Paul D. Adams, Ralf W. Grosse‐Kunstleve, Li‐Wei Hung et al. · Acta Crystallographica Section D Biological Crystallography · 2002 · 4.4K citations · Full text

Crystal Structure, Engineering, Structural Bioinformatics +18

The structure of β-lactamases

R P Ambler · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1980 · 1.8K citations

Class B, Homology Group, Antibiotics +12

Protein stability promotes evolvability

Jesse D. Bloom, Sy T. Labthavikul, Christopher R. Otey et al. · Proceedings of the National Academy of Sciences · 2006 · 1.2K citations · Full text

Protein Assembly, Molecular Biology, Mutational Robustness +17

Enzyme Structure and Mechanism

H. Gutfreund · FEBS Letters · 1978 · 760 citations · Full text

Chemical Catalysis, Enzymology, Steady State Kinetics +12

A relationship between protein stability and protein function.

B.K. Shoichet, W.A. Baase, Ryota Kuroki et al. · Proceedings of the National Academy of Sciences · 1995 · 726 citations · Full text

Protein Chemistry, Protein Function, Biochemistry +13