Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice

The new enzymology of precursor processing endoproteases.

Donald F. Steiner, Steven P. Smeekens, Shinya Ohagi et al. · Journal of Biological Chemistry · 1992 · 612 citations · Full text

Precursor Processing Endoproteases, Biotransformation, Cellular Enzymology +2

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

Suzanne Benjannet, Normand Rondeau, Robert Day et al. · Proceedings of the National Academy of Sciences · 1991 · 594 citations · Full text

Protein Secretion, Regulated Secretion, Viral Pathogenesis +23

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

Steven P. Smeekens, Donald F. Steiner · Journal of Biological Chemistry · 1990 · 578 citations · Full text

Molecular Biology, Mammalian Kex2/subtilisin-like Proteases, Pc2 Protein +16

Cloning and Primary Sequence of a Mouse Candidate Prohormone Convertase PC1 Homologous to PC2, Furin, and Kex2: Distinct Chromosomal Localization and Messenger RNA Distribution in Brain and Pituitary Compared to PC2

Nabil G. Seidah, M. Marcinkiewicz, Suzanne Benjannet et al. · Molecular Endocrinology · 1991 · 478 citations · Full text

Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2

Machi Furuta, Hideki Yano, An Zhou et al. · Proceedings of the National Academy of Sciences · 1997 · 424 citations · Full text