Antiallergic Effects of Lactobacillus pentosus Strain S-PT84 Mediated by Modulation of Th1/Th2 Immunobalance and Induction of IL-10 Production

Abstract

Despite heat-killing, S-PT84 exhibited antiallergic effects by modulating the Th1/Th2 balance and inducing regulatory T cells. The L. pentosus strain S-PT84, which is of plant origin and isolated from a traditional Japanese food, is expected to be useful for treatment of many immune diseases including allergies, tumors, infectious diseases and auto-immune diseases.

References

Page 1

	Year	Citations
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial Marko Kalliomäki, Seppo Salminen, Heikki Arvilommi, The Lancet NutritionPrimary PreventionProbioticPreventive MedicineAllergy	2001	2.4K
Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial Marko Kalliomäki, Seppo Salminen, Tuija Poussa, The Lancet ProbioticPreventive MedicineAllergyAtopic DermatitisAllergy Medicine	2003	1.3K
Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells Susanne J. Szabo, Anand S. Dighe, Ueli Gubler, The Journal of Experimental Medicine Adaptive Immune Systemβ2 Subunit ExpressionTh2 PathwayImmune RegulationImmunology	1997	1K
Probiotics in the management of atopic eczema Erika Isolauri, Taina Arvola, Y. Sütas, Clinical & Experimental Allergy	2000	980
Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. Hervé Groux, Mike Bigler, J E de Vries, The Journal of Experimental Medicine Adaptive Immune SystemT-regulatory CellImmunologyImmunologic MechanismCd4 T Cell Responses	1996	773
Selective probiotic bacteria induce IL-10–producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell–specific intercellular adhesion molecule 3–grabbing nonintegrin Hermelijn H. Smits, Anneke Engering, Desirée van der Kleij, Journal of Allergy and Clinical Immunology InflammationProbioticImmune Effector FunctionsMedicineImmune Regulation	2005	748
The epidemic of allergy and asthma Stephen T. Holgate Nature AsthmaEnvironmental AllergyAllergyAllergy MedicinePeanut Allergy	1999	591
The Probiotic Bacterium <i>Lactobacillus casei</i> Induces Activation of the Gut Mucosal Immune System through Innate Immunity Carolina Maldonado Galdeano, Gabriela Perdigón Clinical and Vaccine Immunology	2006	527
Enhanced antiinflammatory capacity of a <i>Lactobacillus plantarum</i> mutant synthesizing modified teichoic acids Corinne Grangette, Sophie Nutten, Emmanuelle Palumbo, Proceedings of the National Academy of Sciences	2005	432
Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. Sylvie Trembleau, Giuseppe Penna, Emanuele Bosi, The Journal of Experimental Medicine T-regulatory CellImmunologyImmune RegulationImmunologic MechanismCd4 T Cell Responses	1995	421

Page 1