Oral benfotiamine plus α-lipoic acid normalises complication-causing pathways in type 1 diabetes

The Pathobiology of Diabetic Complications

Michael Brownlee · Diabetes · 2005 · 5.1K citations · Full text

Family Medicine, Metabolic Syndrome, Type 1 +13

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

Hans-Peter Hammes, Xueliang Du, Diane Edelstein et al. · Nature Medicine · 2003 · 777 citations

Metabolic Syndrome, Diabetic Retinopathy, Ocular Disease +12

Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine

Roya Babaei‐Jadidi, N. Karachalias, Naila Ahmed et al. · Diabetes · 2003 · 373 citations · Full text

Renal Inflammation, High-dose Thiamine, Insulin Signaling +19

Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation

Xueliang Du, Diane Edelstein, Silvana Obici et al. · Journal of Clinical Investigation · 2006 · 346 citations · Full text

Lipid Peroxidation, Insulin Signaling, Redox Biology +19

High Glucose via Peroxynitrite Causes Tyrosine Nitration and Inactivation of Prostacyclin Synthase That Is Associated With Thromboxane/Prostaglandin H2 Receptor–Mediated Apoptosis and Adhesion Molecule Expression in Cultured Human Aortic Endothelial Cells

Ming-Hui Zou, Chaomei Shi, Richard A. Cohen · Diabetes · 2002 · 260 citations · Full text

Vascular Disease, High Glucose, Nitric Oxide +19