Hypoxia-mediated control of HIF/ARNT machinery in epidermal keratinocytes

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations · Full text

Genetics, Molecular Biology, Hif-1 Subunits +21

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

Eric Huang, Jie Gu, Maureen Schau et al. · Proceedings of the National Academy of Sciences · 1998 · 2.1K citations · Full text

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

David Lando, Daniel J. Peet, Jeffrey J. Gorman et al. · Genes & Development · 2002 · 1.5K citations · Full text

Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

Bing‐Hua Jiang, Elizabeth Rue, Guang L. Wang et al. · Journal of Biological Chemistry · 1996 · 1.1K citations · Full text

Human Keratinocytes That Express hTERT and Also Bypass a p16^INK4a-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics

Mark A. Dickson, William C. Hahn, Yasushi Ino et al. · Molecular and Cellular Biology · 2000 · 1.1K citations

Retain Normal Growth, Telomerase Expression, Skin Development +13