Fast and accurate short read alignment with Burrows–Wheeler transform

Heng Li, Richard Durbin

Bioinformatics

A framework for variation discovery and genotyping using next-generation DNA sequencing data

Mark A. DePristo, Eric Banks, Ryan Poplin, +15

Nature Genetics

Dna SequencingSequencingMedicineGeneticsComputational Genomics +12

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert, +8

Nature

Regenerative MedicineCell LineageCrypt-villus StructuresDevelopmental BiologyMedicine +7

Integrative Genomic Profiling of Human Prostate Cancer

Barry S. Taylor, Nikolaus Schultz, Haley Hieronymus, +23

Cancer Cell

UrologyFunctional GenomicsIntegrative Genomic ProfilingGenitourinary CancerCancer Genomics +3

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

Toshiro Sato, Daniel E. Stange, Marc Ferrante, +8

Gastroenterology

Gastrointestinal OncologyMedicineGastroenterologyColorectal CancerPathology +5

The mutational landscape of lethal castration-resistant prostate cancer

Catherine S. Grasso, Yi-Mi Wu, Dan R. Robinson, +24

Nature

UrologySomatic VariantGenitourinary CancerMutational LandscapeProstatic Disease

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Meritxell Huch, Craig Dorrell, Sylvia F. Boj, +11

Nature

Regenerative MedicineVitro ExpansionDevelopmental BiologyMedicineWnt-driven Regeneration +6

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

Nick Barker, Meritxell Huch, Pekka Kujala, +14

Cell stem cell

Developmental BiologyMedicineAdult Stem CellStem Cell ResearchStem Cells +2

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

Dong Gao, Ian Vela, Andrea Sboner, +36

Cell

Organoid Cultures DerivedUrologyMedicineOrganoid ModelsProstatic Disease +1

Pten is essential for embryonic development and tumour suppression

Antonio Di Cristofano, Bárbara Pesce, Carlos Cordon‐Cardo, +1

Nature Genetics

Developmental BiologyCell ProliferationTumour SuppressionTumor SuppressorMedicine +2