Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

Joseph L. Goldstein, Y K Ho, Sandip K. Basu et al. · Proceedings of the National Academy of Sciences · 1979 · 2.5K citations · Full text

Life Sciences, Biochemistry, Immunology +17

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Andrew Plump, Jonathan D. Smith, Tony Hayek et al. · Cell · 1992 · 2.3K citations

Life Sciences, Genetics, Molecular Genetics +10

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

Seppo Ylä‐Herttuala, Wulf Palinski, Michael E. Rosenfeld et al. · Journal of Clinical Investigation · 1989 · 1.9K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations

David W. Bilheimer, Shlomo Eisenberg, Robert I. Levy · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1972 · 1.8K citations

Life Sciences, Biochemistry, Molecular Biology +9

Low density lipoprotein undergoes oxidative modification in vivo.

Wulf Palinski, Michael E. Rosenfeld, Seppo Ylä‐Herttuala et al. · Proceedings of the National Academy of Sciences · 1989 · 1.5K citations · Full text

Life Sciences, Biochemistry, Pathobiology +17