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Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility

Irina Voineagu, Christine Surka, A.A. Shishkin, Maria M. Krasilnikova, Sergei M. Mirkin

Nature Structural & Molecular Biology · 2009 · 123 citations · 18 references

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18

Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox

Ying‐Hui Fu, Derek P.A. Kuhl, Antonio Pizzuti et al. · Cell · 1991 · 2.1K citations

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S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

Yuki Katou, Yutaka Kanoh, Masashige Bando et al. · Nature · 2003 · 653 citations

, , +14

Trinucleotide repeats that expand in human disease form hairpin structures in vitro

A. Marquis Gacy, Geoffrey M. Goellner, Nenad Juranić et al. · Cell · 1995 · 576 citations

, , +10

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53

Alexander J. Osborn, Stephen J. Elledge · Genes & Development · 2003 · 381 citations · Full text

, , +17

The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure.

Michael Fry, L A Loeb · Proceedings of the National Academy of Sciences · 1994 · 320 citations

, , +11