NM 283, AN EFFICIENT PRODRUG OF THE POTENT ANTI-HCV AGENT 2′-<i>C</i>-METHYLCYTIDINE

Abstract

In order to improve the oral bioavailability of 2-C-methylcytidine, a potent anti-HCV agent, the corresponding 3'-O-L-valinyl ester derivative (NM 283) has been synthesized Based on its ease of synthesis and its physicochemical properties, NM 283 has emerged as a promising antiviral drug for treatment of chronic HCV infection.