Synthesis and Pharmacokinetics of Valopicitabine (NM283), an Efficient Prodrug of the Potent Anti-HCV Agent 2‘-<i>C</i>-Methylcytidine

Claire Pierra, Agnès Amador, S. Benzaria, +10

Journal of Medicinal Chemistry

Rational design for cytosolic delivery of nucleoside monphosphates : “SATE” and “DTE” as enzyme-labile transient phosphate protecting groups

Christian Périgaud, Gilles Gosselin, Isabelle Lefèbvre, +4

Bioorganic & Medicinal Chemistry Letters

Nucleic Acid ChemistryCellular EnzymologyBiochemistryRational DesignNatural Sciences +7

Synthesis, <i>in Vitro</i> Antiviral Evaluation, and Stability Studies of Bis(<i>S</i>-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability

S. Benzaria, Hélène Pelicano, R. Jeremy Johnson, +5

Journal of Medicinal Chemistry

Pmea ProdrugsMedicinal ChemistryImproved Oral BioavailabilityBioorganic ChemistryPharmaceutical Chemistry +13

Conformationally Constrained Analogues of Diacylglycerol (DAG). 16. How Much Structural Complexity Is Necessary for Recognition and High Binding Affinity to Protein Kinase C?

Kassoum Nacro, Bruno Bienfait, Jeewoo Lee, +7

Journal of Medicinal Chemistry

Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA BIS(SATE)phosphotriester and 3′-azido-2′,3′-dideoxythymidine

Christian Pericaud, Anne-Marie Aubertin, S. Benzaria, +6

Biochemical Pharmacology

Viral ReplicationHuman RetrovirusImmunologyAntiviral ResponseImmunodominance +9

NM 283, AN EFFICIENT PRODRUG OF THE POTENT ANTI-HCV AGENT 2′-<i>C</i>-METHYLCYTIDINE

Claire Pierra, S. Benzaria, A. Amador, +4

Nucleosides Nucleotides & Nucleic Acids

Medicinal ChemistryNm 283Oral BioavailabilityBiochemistryMedicine +11

2′-<i>C</i>-Methyl Branched Pyrimidine Ribonucleoside Analogues: Potent Inhibitors of RNA Virus Replication

S. Benzaria, Dorothée Bardiot, Tony Bouisset, +21

Antiviral chemistry & chemotherapy

Viral ReplicationBioorganic ChemistryViral Polymerase StructureViral Polymerase MechanismMolecular Biology +15

New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy.

G. Gosselin, Jean‐Luc Girardet, Christian Périgaud, +5

Acta Biochimica Polonica

Enzyme-mediated Bio-labile ProtectionBioorganic ChemistryCell Culture SystemsImmunologyMolecular Biology +21

NM 283 has potent antiviral activity against genotype 1 chronic hepatitis C virus (HCV-1) infection in the chimpanzee

David N. Standring, Robert E. Lanford, Teresa L. Wright, +15

Journal of Hepatology

Nm 283Hepatitis CViral HepatitisAntiviral ActivityMedicine +8

Conformationally constrained analogues of diacylglycerol (DAG). 15.1 The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C)

S. Benzaria, Bruno Bienfait, Kassoum Nacro, +5

Bioorganic & Medicinal Chemistry Letters

Proteinlipid InteractionBiochemistryNatural SciencesMolecular BiologyConformational Study +4