Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation process

Frédéric Puech, Gilles Gosselin, Isabelle Lefèbvre, +4

Antiviral Research

Signal TransductionIntracellular DeliveryBiochemistryCellular EnzymologyBiochemical Interaction +5

Synthesis, <i>in Vitro</i> Antiviral Evaluation, and Stability Studies of Bis(<i>S</i>-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability

S. Benzaria, Hélène Pelicano, R. Jeremy Johnson, +5

Journal of Medicinal Chemistry

Pmea ProdrugsMedicinal ChemistryImproved Oral BioavailabilityBioorganic ChemistryPharmaceutical Chemistry +13

Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA BIS(SATE)phosphotriester and 3′-azido-2′,3′-dideoxythymidine

Christian Pericaud, Anne-Marie Aubertin, S. Benzaria, +6

Biochemical Pharmacology

Viral ReplicationHuman RetrovirusImmunologyAntiviral ResponseImmunodominance +9

Synthesis and Antiviral Activity of Ethidium−Arginine Conjugates Directed Against the TAR RNA of HIV-1

Valérie Peytou, Roger Condom, Nadia Patino, +6

Journal of Medicinal Chemistry

Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir

Marielle Rouquayrol, Bérangère Gaucher, Jacques Greiner, +3

Carbohydrate Research

Medicinal ChemistryAnti-hiv ActivityMedicineImmunologyAntiviral Drug Development +7

Cyclic PNA-based compound directed against HIV-1 TAR RNA: modelling, liquid-phase synthesis and TAR bindingElectronic supplementary information (ESI) available: experimental details. See http://www.rsc.org/suppdata/ob/b3/b311775h/

Geoffrey Depecker, Nadia Patino, Christophe Di Giorgio, +5

Organic & Biomolecular Chemistry

Bioorganic ChemistryCyclic PnaMolecular BiologyAntiviral DrugChemical Biology +16

Phenyl phosphotriester derivatives of AZT: Variations upon the SATE moiety

Anne‐Laure Villard, G. Coussot, Isabelle Lefèbvre, +5

Bioorganic & Medicinal Chemistry

EngineeringSate MoietyOrganic ChemistryChemistryBiomolecular Engineering

Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative

David Egron, Christian Périgaud, Gilles Gosselin, +5

Bioorganic & Medicinal Chemistry Letters

Adenallene Anti-hiv ActivityBiochemistryMedicineAntiviral Drug DevelopmentCell Culture +5

Amphiphilic Anionic Analogues of Galactosylceramide:  Synthesis, Anti-HIV-1 Activity, and gp120 Binding

Barbara Faroux-Corlay, Jacques Greiner, Raphaël Terreux, +4

Journal of Medicinal Chemistry

Bioorganic ChemistryGlycobiologyGp120 InsertionAntiviral DrugPharmaceutical Chemistry +15

Stereospecific synthesis and biological evaluations of β-l-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine

Jean-François Griffon, Christophe Mathé, Abdesslem Faraj, +5

European Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryStereospecific SynthesisBiochemistryBiological Evaluations +6