Sequential Operation of Ceramide Synthesis and ICE Cascade in CPT-11-Initiated Apoptotic Death Signaling

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 54.9K citations

Cellular Growth, Rapid Colorimetric Assay, Cytotoxicity Assays +11

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature · 1995 · 4K citations

Protein Function, Biochemistry, Ice/ced-3 Protease +11

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

Cell · 1993 · 2.5K citations · Full text

Cytokine, Signaling Pathway, Cell Regulation +11

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

Muneesh Tewari, Long T. Quan, Karen O’Rourke et al. · Cell · 1995 · 2.4K citations · Full text

Mammalian Homolog, Protein Function, Protein Expression +11

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

Masahiko Miura · Cell · 1993 · 1.4K citations

Signaling Pathway, Death Gene Ced-3, Medicine +9