Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

Luca Santarelli, Michael Saxe, Cornelius T. Gross et al. · Science · 2003 · 4.3K citations · Full text

Neuropsychology, Psychotropic Medication, Chronic Antidepressants +18

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

Denis J. David, Benjamin A. Samuels, Quentin Rainer et al. · Neuron · 2009 · 1.2K citations · Full text

Stress Hormone, Psychiatry, Behavioral Neuroscience +12

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

Merja Lakso, José G. Pichel, James Gorman et al. · Proceedings of the National Academy of Sciences · 1996 · 1.1K citations · Full text

Transgenic Mouse Models, Genetics, Molecular Genetics +18

IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress

Ja Wook Koo, Ronald S. Duman · Proceedings of the National Academy of Sciences · 2008 · 839 citations · Full text

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

Katja Wiegmann, Stefan Schütze, Thomas Machleidt et al. · Cell · 1994 · 724 citations

Inflammation, Tumor Necrosis Factor, Signal Transduction +10