Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

Kenneth W. Culver, Zvi Ram, Stuart Wallbridge et al. · Science · 1992 · 1.5K citations

In Vivo Gene Therapy, Neural Stem Cell, Gene Delivery +18

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells

Zvi Ram, Kenneth W. Culver, Eric M. Oshiro et al. · Nature Medicine · 1997 · 682 citations

Neuro-oncology, Medicine, Viral Oncology +6

Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.

S H Chen, H. David Shine, J. Clay Goodman et al. · Proceedings of the National Academy of Sciences · 1994 · 481 citations · Full text

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials

Ricardo A. Dewey, Graham Morrissey, Christine M. Cowsill et al. · Nature Medicine · 1999 · 314 citations

Thymidine Kinase Expression, Neuro-oncology, Cancer-associated Virus +13

Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.

David Barba, James W. Hardin, M Sadelain et al. · Proceedings of the National Academy of Sciences · 1994 · 299 citations · Full text

Cell Therapy, Immunology, Cell Death +20