Epigenetic alterations by methylation of RASSF1A and DAPK1 promoter sequences in mammary carcinoma detected in extracellular tumor DNA

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

James G. Herman, Jeremy R. Graff, Sanna Myöhänen et al. · Proceedings of the National Academy of Sciences · 1996 · 5.7K citations

Life Sciences, Genetics, Molecular Biology +17

CpG island methylator phenotype in colorectal cancer

Minoru Toyota, Nita Ahuja, Mutsumi Ohe-Toyota et al. · Proceedings of the National Academy of Sciences · 1999 · 2.5K citations

Medicine, Genetics, Oncology +17

Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis

Yuk Ming Dennis Lo, Mark Tein, Tze Kin Lau et al. · The American Journal of Human Genetics · 1998 · 1.7K citations

Medicine, Maternal Health, Obstetrics +14

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

Manel Esteller, Montse Sánchez‐Céspedes, Rafael Rosell et al. · PubMed · 1999 · 928 citations

Medicine, Molecular Biology, Oncology +17

Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples

David Sidransky, Andrew von Eschenbach, Yvonne Tsai et al. · Science · 1991 · 894 citations

Medicine, Genetics, Oncology +13