Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Hannah Farmer, Nuala McCabe, Christopher J. Lord, +11

Nature

Genome InstabilityDna DamageBrca Mutant CellsMedicineMolecular Biology +5

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

Jim Miller, A. McLachlan, A. Klug

The EMBO Journal

OocyteTranscriptional RegulationXenopus OocytesDevelopmental BiologySignal Transduction +8

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

Damien D’Amours, Serge Desnoyers, Icy D’Silva, +1

Biochemical Journal

BiochemistryDna MetabolismNatural SciencesProtein BiosynthesisNew Poly +9

XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

Murielle Masson, Claude Niedergang, Valérie Schreiber, +3

Molecular and Cellular Biology

Poly(ADP-ribose) Binds to Specific Domains in DNA Damage Checkpoint Proteins

Jutta M. Pleschke, Hanna E. Kleczkowska, Mark Strohm, +1

Journal of Biological Chemistry

ChromatinGenome InstabilityNuclear ExportProtein FunctionSpecific Domains +9

The macro domain is an ADP‐ribose binding module

Georgios Ioannis Karras, Georg Kustatscher, Heeran R Buhecha, +5

The EMBO Journal

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

Daniel M. Scolnick, Thanos D. Halazonetis

Nature

MitophagySignal TransductionCell RegulationCell DivisionCell Signaling +8

Physical and Functional Interaction between DNA Ligase IIIα and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair

John B. Leppard, Zhiwan Dong, Zachary B. Mackey, +1

Molecular and Cellular Biology

Chfr is required for tumor suppression and Aurora A regulation

Xiaochun Yu, Katherine Minter‐Dykhouse, Liviu Malureanu, +8

Nature Genetics

Cancer ResearchSignal TransductionSignaling PathwayCell RegulationMolecular Regulation +8

The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition

Dongmin Kang, James Chen, Jim Wong, +1

The Journal of Cell Biology

Molecular RegulationCheckpoint Protein ChfrMolecular BiologyCell DeathInhibits Cdc2 +16