Arachidonate 5-Lipoxygenase Establishes Adaptive Humoral Immunity by Controlling Primary B Cells and Their Cognate T-Cell Help

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Masamichi Muramatsu, Kazuo Kinoshita, Sidonia Fagarasan et al. · Cell · 2000 · 3.4K citations

Natural Sciences, Genetics, Rna Biology +7

Bcl6 Mediates the Development of T Follicular Helper Cells

Roza Nurieva, Yeonseok Chung, Gustavo Martínez et al. · Science · 2009 · 1.5K citations · Full text

Bcl6 Deficiency, Lymphocyte Development, Adaptive Immune System +16

A Critical Role for IL-21 in Regulating Immunoglobulin Production

Katsutoshi Ozaki, Rosanne Spolski, Carl G. Feng et al. · Science · 2002 · 956 citations

Primary Immunodeficiency, Inflammation, Regulating Immunoglobulin Production +14

IFN- <i>gamma</i> regulates the isotypes of Ig secreted during in vivo humoral immune responses.

Fred D. Finkelman, Ildy M. Katona, Tim R. Mosmann et al. · The Journal of Immunology · 1988 · 721 citations · Full text

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

Aurélie Bauquet, Hulin Jin, Alison M. Paterson et al. · Nature Immunology · 2008 · 701 citations · Full text

Inflammation, Cytokine, Autoimmune Disease +10