Concepedia

Stereoselective Synthesis of 2-(2-Hydroxyalkyl)piperidine Alkaloids Through Prins–Ritter Reaction

B. V. Subba Reddy, Supriya Ghanty, N. Siva Senkar Reddy, Y. Jayasudhan Reddy, Jagjit S. Yadav

Synthetic Communications · 2014 · 15 citations · 10 references

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Abstract

Abstract A stereoselective total synthesis of the 2-(2-hydroxyalkyl)piperidine alkaloids has been accomplished by a Prins–Ritter amidation sequence. Other steps involved in this synthesis are Jacobsen's hydrolytic kinetic resolution (HRK) and ring-closing metathesis (RCM).

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